Total synthesis of atropodiastereomers of heterodimeric Amaryllidaceae alkaloids: narcipavline and narcikachnine

The first asymmetric total synthesis of naturally occurring atropodiastereomers of Amaryllidaceae alkaloids, such as narcipavlines A (1a) and B (1b) and narcikachnines A (2a) and B (2b), sharing a cis -dihydrobenzofuran structure is reported.