腺苷
清醒
神经科学
光遗传学
唤醒
基底前脑
星形胶质细胞
非快速眼动睡眠
腺苷A1受体
运动前神经元活动
腺苷受体
化学
内科学
内分泌学
生物
医学
受体
中枢神经系统
眼球运动
脑电图
兴奋剂
作者
Yuwei Zhu,Junli Ma,Yulan Li,Meng-Yang Gu,Xiang Feng,Yujin Shao,Lei Tan,Hui‐fang Lou,Li Sun,Yijun Liu,Linghui Zeng,Zilong Qiu,Xiaoming Li,Shumin Duan,Yan‐Qin Yu
标识
DOI:10.1002/advs.202407706
摘要
Abstract Astrocytes play a crucial role in regulating sleep‐wake behavior. However, how astrocytes govern a specific sleep‐arousal circuit remains unknown. Here, the authors show that parafacial zone (PZ) astrocytes responded to sleep‐wake cycles with state‐differential Ca 2+ activity, peaking during transitions from sleep to wakefulness. Using chemogenetic and optogenetic approaches, they find that activating PZ astrocytes elicited and sustained wakefulness by prolonging arousal episodes while impeding transitions from wakefulness to non‐rapid eye movement (NREM) sleep. Activation of PZ astrocytes specially induced the elevation of extracellular adenosine through the ATP hydrolysis pathway but not equilibrative nucleoside transporter (ENT) mediated transportation. Strikingly, the rise in adenosine levels induced arousal by activating A 1 receptors, suggesting a distinct role for adenosine in the PZ beyond its conventional sleep homeostasis modulation observed in the basal forebrain (BF) and cortex. Moreover, at the circuit level, PZ astrocyte activation induced arousal by suppressing the GABA release from the PZ GABA neurons, which promote NREM sleep and project to the parabrachial nucleus (PB). Thus, their study unveils a distinctive arousal‐promoting effect of astrocytes within the PZ through extracellular adenosine and elucidates the underlying mechanism at the neural circuit level.
科研通智能强力驱动
Strongly Powered by AbleSci AI