Ubiquitin‐Proteasome System in Periodontitis: Mechanisms and Clinical Implications

牙周炎 脱氮酶 泛素 生物 蛋白酶体 Wnt信号通路 机制(生物学) 细胞生物学 信号转导 癌症研究 医学 遗传学 基因 哲学 认识论 内科学
作者
Yilin Ma,Ru Jia,Shuhong Chen,Jun Ma,Lei Yin,Xiongxiong Pan,Yanli He,Tong Wu,Zheyu Zhao,Liheng Ma,Shengzhuang Wu,Huining Wang,Guang Liang,Shengbin Huang,Xiaoyu Sun
出处
期刊:Cell Proliferation [Wiley]
标识
DOI:10.1111/cpr.13781
摘要

ABSTRACT The progression of periodontitis, a bacteria‐driven inflammatory and bone‐destructive disease, involves myriad cellular and molecular mechanisms. Protein regulation significantly influences the pathogenesis and management of periodontitis. However, research regarding its regulatory role in periodontitis remains relatively limited. The ubiquitin‐proteasome system (UPS), which mainly involves ubiquitination by E3 ubiquitin ligases (E3s) and deubiquitination by deubiquitinating enzymes (DUBs), is the primary intracellular and non‐lysosomal mechanism of protein degradation. Recent studies have provided compelling evidence to support the involvement of UPS in periodontitis progression. Increasing evidence indicated that E3s, such as CUL3, Nedd4‐2, Synoviolin, FBXL19, PDLIM2, TRIMs and TRAFs, modulate inflammatory responses and bone resorption in periodontitis through multiple classical signalling pathways, including NLRP3, GSDMD, NF‐κB, Wnt/β‐catenin and Nrf2. Meanwhile, DUBs, including OTUD1, A20, CYLD, UCH‐L1 and USPs, also broadly modulate periodontitis progression by regulating signalling pathways such as NF‐κB, Wnt/β‐catenin, NLRP3, and BMP2. Therefore, the modulation of E3s and DUBs has proven to be an effective therapy against periodontitis. This review provides a comprehensive overview of the regulatory role of ubiquitinating and deubiquitinating enzymes in periodontitis progression and the underlying mechanisms. Finally, we summarise several chemical and genetic methods that regulate UPS enzymes and pave the way for the development of targeted therapies for periodontitis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
我是老大应助露亮采纳,获得10
3秒前
顾矜应助Bressanone采纳,获得10
3秒前
阳光发布了新的文献求助10
4秒前
半夏发布了新的文献求助10
5秒前
6秒前
7秒前
Miracle_wh完成签到,获得积分10
7秒前
8秒前
Miracle_wh发布了新的文献求助10
10秒前
12秒前
12秒前
13秒前
13秒前
圆月弯刀完成签到 ,获得积分10
14秒前
坦率白萱应助DJANGO采纳,获得30
16秒前
露亮完成签到,获得积分10
17秒前
Bressanone发布了新的文献求助10
17秒前
18秒前
斯文的慕儿完成签到 ,获得积分10
20秒前
露亮发布了新的文献求助10
20秒前
20秒前
智慧少女不头秃完成签到,获得积分10
22秒前
33完成签到,获得积分10
23秒前
所所应助感谢有你采纳,获得10
25秒前
25秒前
26秒前
27秒前
乐乐应助anna采纳,获得10
30秒前
潇湘雪月发布了新的文献求助10
30秒前
30秒前
刘燕发布了新的文献求助10
31秒前
31秒前
32秒前
量子星尘发布了新的文献求助10
35秒前
俏皮芷蕊发布了新的文献求助10
35秒前
36秒前
39秒前
39秒前
40秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989242
求助须知:如何正确求助?哪些是违规求助? 3531393
关于积分的说明 11253753
捐赠科研通 3270010
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136