光遗传学
神经科学
扁桃形结构
丘脑
回避学习
心理学
刺激(心理学)
生物
认知心理学
作者
Ruining Hu,Nannan Wu,Tong Liu,Lei Zou,Songjie Lv,Xiao Hu,Rongfeng K. Hu
标识
DOI:10.7554/elife.104643.1
摘要
Active avoidance is a type of instrumental behavior that requires an organism actively to engage in specific actions to avoid or escape from a potentially aversive stimulus and is crucial for the survival and well-being of organisms. It requires a widely distributed, hard-wired neural circuits spanning multiple brain regions, including the amygdala and thalamus. However, less is known about whether and how the hypothalamus encodes and controls active avoidance learning. Here we identify a previously unknown role for the parasubthalamic nucleus (PSTN), located in the lateral subdivision of the posterior hypothalamus, in the encoding and control of active avoidance learning. Fiber photometry calcium imaging shows that the activity of tachykinin1-expressing PSTN (PSTN Tac1 ) neurons progressively increases during this learning. Cell-type specific ablation and optogenetic inhibition of PSTN Tac1 neurons attenuates active avoidance learning, whereas optogenetic activation of these cells promotes this learning via a negative motivational drive. Moreover, the PSTN mediates this learning differentially through its downstream targets. Together, this study identifies the PSTN as a new member of the neural networks involved in active avoidance learning and offers us potential implications for therapeutic interventions targeting anxiety disorders and other conditions involving maladaptive avoidance learning.
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