The clinical and pathological evaluation of patients with immunoglobulin a nephropathy by diffusion tensor imaging and intravoxel incoherent motion diffusion-weighted imaging

盒内非相干运动 医学 部分各向异性 磁共振弥散成像 磁共振成像 肾病 病态的 有效扩散系数 病理 胃肠病学 泌尿科 内科学 核医学 放射科 内分泌学 糖尿病
作者
Huan Zhou,Si Yi,Jing Wang,Yi Wang,Yitian Xiao,Yi Tang,Wei Qin
出处
期刊:British Journal of Radiology [British Institute of Radiology]
标识
DOI:10.1093/bjr/tqae132
摘要

Abstract Objectives To explore the efficacy of diffuse magnetic resonance imaging (MRI) for identifying clinicopathological changes in immunoglobulin A nephropathy (IgAN) patients. Methods The study enrolled IgAN patients and healthy volunteers. IgAN patients were divided into group 1 (eGFR ≥ 90 ml/min/1.73m2), group 2 (60 ≤ eGFR < 90 ml/min/1.73m2), and group 3 (eGFR < 60 ml/min/1.73m2). Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and diffusion tensor imaging (DTI) were performed via 3.0 T magnetic resonance. Diffuse MRI, clinical, and pathological indicators were collected and analyzed. P < 0.05 was considered statistically significant. Results Forty-six IgAN patients and twenty-seven volunteers were enrolled. The apparent diffusion coefficient (ADC), diffusion coefficient (D), perfusion fraction (f), and fractional anisotropy (FA) were significantly different among IgAN subgroups and controls. These parameters were positively correlated with eGFR and negatively with creatinine, and inversely correlated with glomerular sclerosis, interstitial fibrosis, and tubular atrophy (all P < 0.05). They had significantly high area under the curve (AUC) for distinguishing IgAN patients from controls, while FA had the highest AUC in identifying Group 1 IgAN patients from volunteers. Conclusions DTI and IVIM-DWI had the advantage of evaluating clinical and pathological changes in IgAN patients. DTI was superior at distinguishing early IgAN patients and might be a noninvasive marker for screening early IgAN patients from healthy individuals. Advances in knowledge DTI and IVIM-DWI could evaluate clinical and pathological changes and correlated with Oxford classification in IgAN patients. They could also identify IgAN patients from healthy populations, while DTI had superiority in differentiating early IgAN patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
genomed应助愫问采纳,获得20
1秒前
郑岩狭完成签到 ,获得积分10
1秒前
优雅雁菱完成签到,获得积分10
1秒前
2秒前
3秒前
Singularity发布了新的文献求助10
4秒前
4秒前
毛豆爸爸应助violetyjm采纳,获得20
6秒前
积极南珍发布了新的文献求助100
6秒前
收入股发布了新的文献求助10
6秒前
7秒前
科目三应助Meimei采纳,获得20
7秒前
111111111发布了新的文献求助10
8秒前
8秒前
大模型应助李朝富采纳,获得10
8秒前
10秒前
danrushui777发布了新的文献求助30
10秒前
11秒前
方塘发布了新的文献求助30
11秒前
11秒前
炒栗子发布了新的文献求助10
13秒前
李健的小迷弟应助111111111采纳,获得10
14秒前
研友_8Qxp7Z发布了新的文献求助10
14秒前
SciGPT应助acheng采纳,获得10
14秒前
星河完成签到,获得积分10
15秒前
惜墨应助transition采纳,获得20
15秒前
愉快凌晴发布了新的文献求助10
16秒前
孔建梅完成签到 ,获得积分10
16秒前
HHCC发布了新的文献求助10
16秒前
赘婿应助JaneChen采纳,获得50
16秒前
zz完成签到,获得积分10
17秒前
法号胡来发布了新的文献求助10
17秒前
18秒前
彭于晏应助ssk采纳,获得10
18秒前
刚子发布了新的文献求助10
19秒前
学术羊完成签到,获得积分10
20秒前
20秒前
21秒前
23秒前
呆瓜完成签到,获得积分10
24秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3139078
求助须知:如何正确求助?哪些是违规求助? 2789947
关于积分的说明 7793264
捐赠科研通 2446392
什么是DOI,文献DOI怎么找? 1301085
科研通“疑难数据库(出版商)”最低求助积分说明 626105
版权声明 601102