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Neural responses to decision-making in suicide attempters with youth major depressive disorder

冲动性 爱荷华赌博任务 重性抑郁障碍 心理学 萧条(经济学) 自杀未遂 脑电图 精神科 事件相关电位 临床心理学 意识的神经相关物 自杀意念 年轻人 自杀预防 毒物控制 发展心理学 医学 认知 医疗急救 经济 宏观经济学
作者
Ciqing Bao,Qiaoyang Zhang,Chen He,Haowen Zou,Yi Xia,Rui Yan,Lingling Hua,Xiaoqin Wang,Qing Lü,Zhijian Yao
出处
期刊:NeuroImage: Clinical [Elsevier]
卷期号:43: 103667-103667
标识
DOI:10.1016/j.nicl.2024.103667
摘要

An improved understanding of the factors associated with suicidal attempts in youth suffering from depression is crucial for the identification and prevention of future suicide risk. However, there is limited understanding of how neural activity is modified during the process of decision-making. Our study aimed to investigate the neural responses in suicide attempters with major depressive disorder (MDD) during decision-making. Electroencephalography (EEG) was recorded from 79 individuals aged 16-25 with MDD, including 39 with past suicide attempts (SA group) and 40 without (NSA group), as well as from 40 age- and sex- matched healthy controls (HCs) during the Iowa Gambling Task (IGT). All participants completed diagnostic interviews, self-report questionnaires. Our study examined feedback processing by measuring the feedback-related negativity (FRN), ΔFN (FRN-loss minus FRN-gain), and the P300 as electrophysiological indicators of feedback evaluation. The SA group showed poorest IGT performance. SA group and NSA group, compared with HC group, exhibited specific deficits in decision-making (i.e., exhibited smaller (i.e., blunted) ΔFN). Post hoc analysis found that the SA group was the least sensitive to gains and the most sensitive to losses. In addition, we also found that the larger the value of ΔFN, the better the decision-making ability and the lower the impulsivity. Our study highlights the link between suicide attempts and impaired decision-making in individuals with major depressive disorder. These findings constitute an important step in gaining a better understanding of the specific reward-related abnormalities that could contribute to the young MDD patients with suicide attempts.
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