生物利用度
脂质体
吸收(声学)
赛马鲁肽
化学
钠
吸收效率
药理学
色谱法
医学
生物化学
内分泌学
生物
材料科学
动物科学
糖尿病
利拉鲁肽
2型糖尿病
复合材料
有机化学
作者
Yehan Li,Fei Liu,Jeong‐Hwan Che,Yu Zhang,Tian Yin,Jingxin Gou,Xing Tang,Yanjiao Wang,Haibing He
标识
DOI:10.1016/j.ijpharm.2024.124669
摘要
The aim of this study was to prepare sodium glycocholate liposomes (SGC-Lip) encapsulating semaglutide (Sml) to improve oral bioavailability and better exert hypoglycemic effect. In this paper, SGC-Lip was prepared by reverse-phase evaporation method with particle size around 140 nm, potential around -27 mV, rounded morphology and better stability. The hypoglycemic and intestinal uptake effects of SGC-Lip and cholesterol-containing liposomes (CH-Lip) were comparatively investigated in rats, and the oral safety of SGC-Lip was examined by cytotoxicity assay. The results indicate that SGC-Lip can achieve a hypoglycemic effect of 40% of the initial value within 12 hours, and the AAC
科研通智能强力驱动
Strongly Powered by AbleSci AI