亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Dynamic changes in mechanical properties of the adult rat spinal cord after injury

脊髓损伤 脊髓 医学 麻痹 生物力学 生物医学工程 麻醉 外科 解剖 精神科
作者
Chen Jin,Rui Zhu,Zhanwei Wang,Yi Li,Hao-fei Ni,Menglei Xu,Liang-dong Zheng,Yu-ting Cao,Yiting Yang,Wei Xu,Jianjie Wang,Ning Xie,Liming Cheng
出处
期刊:Acta Biomaterialia [Elsevier BV]
卷期号:155: 436-448 被引量:11
标识
DOI:10.1016/j.actbio.2022.11.041
摘要

Spinal cord injury (SCI), a debilitating medical condition that can cause irreversible loss of neurons and permanent paralysis, currently has no cure. However, regenerative medicine may offer a promising treatment. Given that numerous regenerative strategies aim to deliver cells and materials in the form of tissue-engineered therapies, understanding and characterising the mechanical properties of the spinal cord tissue is very important. In this study, we have systematically characterised the spatiotemporal changes in elastic stiffness (elastic modulus, Pa) and viscosity (drop in peak force, %) of injured rat thoracic spinal cord tissues at distinct time points after crush injury using the indentation technique. Our results demonstrate that in comparison with uninjured spinal cord tissue, the injured tissues exhibited lower stiffness (median 3281 Pa versus 9632 Pa; P < 0.001) but demonstrated elevated viscosity (median 80% versus 57%; P < 0.001) at 3 days postinjury. Between 4 and 6 weeks after SCI, the overall viscoelastic properties of injured tissues returned to baseline values. At 12 weeks after SCI, in comparison with uninjured tissue, the injured spinal cord tissues displayed a significant increase in both elasticity (median 13698 Pa versus 9920 Pa; P < 0.001) and viscosity (median 64% versus 58%; P < 0.001). This work constitutes the first quantitative mapping of spatiotemporal changes in spinal cord tissue elasticity and viscosity in injured rats, providing a mechanical basis of the tissue for future studies on the development of biomaterials for SCI repair. STATEMENT OF SIGNIFICANCE: Spinal cord injury (SCI) is a devastating disease often leading to permanent paralysis. While enormous progress in understanding the molecular pathomechanisms of SCI has been made, the mechanical properties of injured spinal cord tissue have received considerably less attention. This study provides systematic characterization of the biomechanical evolution of rat spinal cord tissue after SCI using a microindentation test method. We find spinal cord tissue behaves significantly softer but more viscous immediately postinjury. As time passes, the lesion site gradually returns to baseline values and then displays pronounced increased viscoelastic properties. As host tissue mechanical properties are a crucial consideration for any biomaterial implanted into central nervous system, our results may have important implications for further studies of SCI repair.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助50
3秒前
4秒前
小二郎应助科研通管家采纳,获得10
8秒前
NexusExplorer应助科研通管家采纳,获得10
9秒前
9秒前
lin完成签到 ,获得积分10
20秒前
25秒前
阿亞完成签到,获得积分10
36秒前
不知道取啥名完成签到 ,获得积分10
41秒前
45秒前
标致荔枝完成签到,获得积分10
47秒前
49秒前
啊啊啊啊啊啊啊啊啊啊完成签到 ,获得积分10
52秒前
半青一江完成签到 ,获得积分10
54秒前
001完成签到,获得积分10
1分钟前
1分钟前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
头孢西丁完成签到 ,获得积分10
1分钟前
隐形曼青应助科研通管家采纳,获得10
2分钟前
Akim应助科研通管家采纳,获得10
2分钟前
上官若男应助科研通管家采纳,获得10
2分钟前
2分钟前
2分钟前
2分钟前
2分钟前
3分钟前
3分钟前
量子星尘发布了新的文献求助10
3分钟前
3分钟前
向日葵的微笑完成签到,获得积分10
3分钟前
3分钟前
3分钟前
领导范儿应助带虾的烧麦采纳,获得10
3分钟前
张杠杠完成签到 ,获得积分10
3分钟前
Zhou完成签到,获得积分10
3分钟前
万能的悲剧完成签到 ,获得积分10
3分钟前
3分钟前
dingheng完成签到,获得积分10
3分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976649
求助须知:如何正确求助?哪些是违规求助? 3520735
关于积分的说明 11204640
捐赠科研通 3257493
什么是DOI,文献DOI怎么找? 1798716
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806613