生物
卵巢储备
环状RNA
卵巢
男科
小RNA
生物信息学
内科学
内分泌学
遗传学
基因
医学
不育
怀孕
作者
Peigen Chen,Wei Li,Xiaoping Liu,Yanfang Wang,Huisi Mai,Rui Huang
出处
期刊:Epigenomics
[Future Medicine]
日期:2022-09-01
卷期号:14 (17): 1029-1038
标识
DOI:10.2217/epi-2022-0211
摘要
Aim: We aimed to determine the role of granulosa cells (GCs) circular RNA (circRNA) in ovarian aging. Methods: Nine women were recruited, including three diminished ovarian reserve young women, three advanced-aged women and three normal ovarian reserve young women. The circRNA expression profiles of GCs were characterized by CLEAR software. Key circRNA were validated by quantitative reverse transcription PCR. Results: GCs in advanced-age group females exhibited active MHC class II-related biological processes. A total of 3575 circRNAs were found in the advanced age group. Hsa-circ-0031584 appears to be one of the important molecules regulating the mitotic process of GCs. Conclusion: The expression profiles of circRNAs exhibited obvious stage specificity with age which might contribute to ovarian aging progression.
科研通智能强力驱动
Strongly Powered by AbleSci AI