硒
化学
毒性
细胞生物学
环境化学
毒理
生物
有机化学
作者
H. Fujita,Yuki Tanaka,Seiryo Ogata,Noriyuki Suzuki,Sota Kuno,Uladzimir Barayeu,Takaaki Akaike,Yasumitsu Ogra,Kazuhiro Iwaï
标识
DOI：10.1038/s41594-024-01329-z
摘要
Ferroptosis is a form of regulated cell death induced by iron-dependent accumulation of lipid hydroperoxides. Selenoprotein glutathione peroxidase 4 (GPX4) suppresses ferroptosis by detoxifying lipid hydroperoxides via a catalytic selenocysteine (Sec) residue. Sec, the genetically encoded 21
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