高脂血症
RNA干扰
核糖核酸
化学
药理学
医学
生物化学
内分泌学
基因
糖尿病
作者
Christie M. Ballantyne,Szilard Vasas,Masoud Azizad,Peter Clifton,Robert S. Rosenson,Ting Chang,Stacey Melquist,Rong Zhou,Ma’an Mushin,Jeremy J. Heit,Jennifer Hellawell,Daniel Gaudet
标识
DOI:10.1056/nejmoa2404143
摘要
Persons with mixed hyperlipidemia are at risk for atherosclerotic cardiovascular disease due to an elevated non-high-density lipoprotein (HDL) cholesterol level, which is driven by remnant cholesterol in triglyceride-rich lipoproteins. The metabolism and clearance of triglyceride-rich lipoproteins are down-regulated through apolipoprotein C3 (APOC3)-mediated inhibition of lipoprotein lipase.
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