免疫系统
肿瘤微环境
腺癌
CD8型
PD-L1
癌症研究
T细胞
医学
生物
免疫学
免疫疗法
内科学
癌症
作者
Maria Auxiliadora de Paula Carneiro Cysneiros,Magno Belém Cirqueira,Lucas de Figueiredo Barbosa,Ênio Chaves de Oliveira,Lúcio Kenny Morais,Isabela Jubé Wastowski,Vitor Gonçalves Floriano
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2024-07-02
卷期号:19 (7): e0305648-e0305648
标识
DOI:10.1371/journal.pone.0305648
摘要
Pancreatic adenocarcinoma is an extremely aggressive neoplasm, with many challenges to be overcome in order to achieve a truly effective treatment. It is characterized by a mostly immunosuppressed environment, with dysfunctional immune cells and active immunoinhibitory pathways that favor tumor evasion and progression. Thus, the study and understanding of the tumor microenvironment and the various cells subtypes and their functional capacities are essential to achieve more effective treatments, especially with the use of new immunotherapeutics.
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