肺表面活性物质
化学
小泡
Zeta电位
溶解度
药物输送
生物相容性
生物利用度
尼奥体
核化学
色谱法
化学工程
有机化学
纳米颗粒
生物化学
膜
工程类
生物
生物信息学
作者
Imdad Ali,Sarzamin Khan,Samrein B. M. Ahmed,Serab Khan,Heyam Saad Ali,Raiz Ullah Shafiullah,Muhammad Raza Shah,Zafar Ali Shah
出处
期刊:Tenside Surfactants Detergents
[De Gruyter]
日期:2023-06-14
卷期号:60 (4): 328-337
标识
DOI:10.1515/tsd-2022-2476
摘要
Abstract In order to improve the solubility and bioavailability of poorly water-soluble drugs, the synthesis of cost-effective nonionic surfactants has been the subject of greater scientific interest. The present study focuses on the synthesis of sulfonyl chloride derivatives as nonionic surfactants (surfactant 1 and surfactant 2 ) and their evaluation for the preparation of a clarithromycin-loaded niosomal drug delivery system. Surfactants 1 and 2 were characterised by EI-MS and 1 H NMR spectroscopy. The shape and size of the drug-loaded niosomal vesicles from the synthesised surfactants were examined by atomic force microscopy (AFM) and revealed a round morphology with an average size of (230.8 ± 2.35) nm and (248.1 ± 2.54) nm for the vesicles of surfactant 1 and surfactant 2 , respectively. The zeta potential of surfactant 1 -based niosomal vesicles was (– 7.70 ± 1.00) mV and that of surfactant 2 was (−14.6 ± 1.08) mV. The lower zeta potential values for surfactant 1 and surfactant 2 -based niosomal vesicles showed that these vesicles were neutral and relatively stable. The vesicles of surfactant 1 and 2 have a capacity to entrap the drug of about (62 ± 2.26) % and (69.67 ± 3.23) %, respectively. The vesicles of surfactant 1 released the largest amount of drug, i.e. (70.00 ± 2.45) % at pH 1.2. Biocompatibility in human blood and toxic effects on various cell lines were also studied for surfactants 1 and 2 , and they were found to be biocompatible and non-cytotoxic.
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