0853 Neighborhood disorder and pain: The mediating role of sleep

Abstract Introduction Neighborhood factors are related to poor sleep, and sleep problems are known to have a strong relationship with pain. The underlying mechanisms for this association remain unclear. The present study evaluated whether sleep duration, sleep quality, or global sleep quality mediated the relation between perceived Neighborhood Disorder (ND) and pain intensity or interference. The study also explored whether adjusting for depressive symptoms accounted for significant mediational pathways found in Aim 1. Methods Participants were drawn from Wave 4 (September 2013 to September 2017) of the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) epidemiologic cohort study (n=1,071). Perceived ND was measured using the HANDLS Neighborhood Problems Scale, which assesses how often a particular neighborhood problem occurs. The Patient Reported Outcomes Measurement Information System Pain Intensity short form 3a was used to assess how much a person hurt in the past 7 days, and pain interference was measured by the bodily pain subdomain of the 12-item Short-Form Health Survey. The Pittsburgh Sleep Quality Index was used to assess sleep duration, subjective sleep quality, and global sleep quality. Results Results of the study revealed mediating effects of global sleep quality on the relation of perceived ND and pain intensity (indirect effect = .5527, SE =.1355, 95% CI [.2914, .8316]) and pain interference (indirect effect = .0579 (SE = .0143), 95% CI [.0312, .0876]) and also of subjective sleep quality on pain intensity (indirect effect = .5801, SE =.1337, 95% CI [.3206, .8468]) and pain interference (indirect effect = .0587 (SE =.0137), 95% CI [.0327, .0867]). Results revealed that mediating effects of sleep quality and global sleep on the relation of perceived ND and pain intensity and pain interference remained significant after adjustment for depressive symptoms. Conclusion These findings provide preliminary evidence to support the notion that select sleep dimensions, particularly sleep quality, is a pathway by which subjective neighborhood factors may impact pain intensity and pain interference. More research is needed to understand potential pathways underlying the perceived ND and pain relation. Support (if any) NIH Intramural Research Program Inter-laboratory proposal provided by the National Institute on Aging Intramural Research Program