Cell competition and the regulation of protein homeostasis

生物 蛋白质稳态 平衡 细胞生物学 细胞 信号转导 细胞生长 调节器 遗传学 基因
作者
Shruthi Krishnan,Pradip Paul,Tristan A. Rodríguez
出处
期刊:Current Opinion in Cell Biology [Elsevier]
卷期号:87: 102323-102323 被引量:1
标识
DOI:10.1016/j.ceb.2024.102323
摘要

The process of embryonic development involves remarkable cellular plasticity, which governs the coordination between cells necessary to build an organism. One role of this plasticity is to ensure that when aberrant cells are eliminated, growth adjustment occurs so that the size of the tissue is maintained. An important regulator of cellular plasticity that ensures cellular cooperation is a fitness-sensing mechanism termed cell competition. During cell competition, cells with defects that lower fitness but do not affect viability, such as those that cause impaired signal transduction, slower cellular growth, mitochondrial dysregulation or impaired protein homeostasis, are killed when surrounded by fitter cells. This is accompanied by the compensatory proliferation of the surviving cells. The underlying factors and mechanisms that demarcate certain cells as less fit than their neighbouring cells and losers of cell competition are still relatively unknown. Recent evidence has pointed to mitochondrial defects and proteotoxic stress as important hallmarks of these loser cells. Here, we review recent advances in this area, focussing on the role of mitochondrial activity and protein homeostasis as major mechanisms determining competitive cell fitness during development and the importance of cell proteostasis in determining cell fitness.
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