Kidney Injury After Minimal Radiographic Contrast Administration in Patients With Acute Coronary Syndromes

医学 经皮冠状动脉介入治疗 急性肾损伤 临床终点 心肌梗塞 肌酐 随机对照试验 内科学 急性冠脉综合征 心脏病学 外科
作者
Carlo Briguori,Cristina Quintavalle,Enrica Mariano,Alessandro D’Agostino,Mario Scarpelli,Amelia Focaccio,Giuseppe Biondi‐Zoccai,Salvatore Evola,Giovanni Esposito,Giuseppe Sangiorgi,Gerolama Condorelli
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:83 (11): 1059-1069 被引量:4
标识
DOI:10.1016/j.jacc.2024.01.016
摘要

Acute kidney injury (AKI) is common in patients with acute coronary syndromes (ACS) treated by percutaneous coronary intervention. Contrast media (CM) volume minimization has been advocated for prevention of AKI. The DyeVert CM diversion system (Osprey Medical, Inc) is designed to reduce CM volume during coronary procedures. In this randomized, single-blind, investigator-driven clinical trial conducted in 4 Italian centers from February 4, 2020 to September 13, 2022, 550 participants with ACS were randomly assigned in a 1:1 ratio to the following: 1) the contrast volume reduction (CVR) group (n = 276), in which CM injection was handled by the CM diversion system; and 2) the control group (n = 274), in which a conventional manual or automatic injection syringe was used. The primary endpoint was the rate of AKI, defined as a serum creatinine (sCr) increase ≥0.3 mg/dL within 48 hours after CM exposure. There were 412 of 550 (74.5%) participants with ST-segment elevation myocardial infarction (211 of 276 [76.4%] in the CVR group and 201 of 274 [73.3%] in the control group). The CM volume was lower in the CVR group (95 ± 30 mL vs 160 ± 23 mL; P < 0.001). Seven participants (1 in the CVR group and 6 in the control group) did not have postprocedural sCr values. AKI occurred in 44 of 275 (16%) participants in the CVR group and in 65 of 268 (24.3%) participants in the control group (relative risk: 0.66; 95% CI: 0.47-0.93; P = 0.018). CM volume reduction obtained using the CM diversion system is effective for prevention of AKI in patients with ACS undergoing invasive procedures. (REnal Insufficiency Following Contrast MEDIA Administration TriaL IV [REMEDIALIV]: NCT04714736)
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
郝老头完成签到,获得积分10
1秒前
13313完成签到,获得积分10
2秒前
su完成签到 ,获得积分10
3秒前
6秒前
11秒前
量子星尘发布了新的文献求助10
11秒前
slayers完成签到 ,获得积分10
11秒前
13秒前
知犯何逆完成签到,获得积分10
15秒前
Krsky完成签到,获得积分10
17秒前
ding应助不安的秋白采纳,获得10
18秒前
19秒前
21秒前
HHHAN发布了新的文献求助10
25秒前
威武的沂完成签到,获得积分10
30秒前
32秒前
33秒前
35秒前
笨笨青筠完成签到 ,获得积分10
38秒前
mengmenglv完成签到 ,获得积分0
38秒前
Tonald Yang完成签到 ,获得积分20
41秒前
42秒前
落后的怀梦完成签到 ,获得积分10
43秒前
陈坤完成签到,获得积分10
45秒前
量子星尘发布了新的文献求助10
47秒前
斯文败类应助zgx采纳,获得10
48秒前
默默完成签到 ,获得积分10
48秒前
KY Mr.WANG完成签到,获得积分10
48秒前
1分钟前
guoxingliu完成签到,获得积分10
1分钟前
1分钟前
阳佟水蓉完成签到,获得积分10
1分钟前
gdgd完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
叮叮当当完成签到,获得积分10
1分钟前
1分钟前
1分钟前
电致阿光完成签到,获得积分10
1分钟前
ccc完成签到 ,获得积分10
1分钟前
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038039
求助须知:如何正确求助?哪些是违规求助? 3575756
关于积分的说明 11373782
捐赠科研通 3305574
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022