肠道菌群
失调
痴呆
疾病
背景(考古学)
神经炎症
生物
认知功能衰退
淀粉样蛋白(真菌学)
氧化应激
阿尔茨海默病
β淀粉样蛋白
神经科学
医学
老年学
生物信息学
病理
免疫学
内科学
古生物学
作者
D.M.S.H. Dissanayaka,Vijay Jayasena,Stephanie R. Rainey‐Smith,Ralph N. Martins,W.M.A.D. Binosha Fernando
出处
期刊:Nutrients
[MDPI AG]
日期:2024-01-31
卷期号:16 (3): 412-412
被引量:18
摘要
Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles. Currently, Alzheimer’s disease (AD) impacts 50 million individuals, with projections anticipating an increase to 152 million by the year 2050. Despite the increasing global prevalence of AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis and treatment. Recent research suggests a link between gut dysbiosis and the aggregation of Aβ, the development of tau proteins, and the occurrence of neuroinflammation and oxidative stress are associated with AD. However, investigations into the gut–brain axis (GBA) in the context of AD progression and pathology have yielded inconsistent findings. This review aims to enhance our understanding of microbial diversity at the species level and the role of these species in AD pathology. Additionally, this review addresses the influence of confounding elements, including diet, probiotics, and prebiotics, on AD throughout different stages (preclinical, mild cognitive impairment (MCI), and AD) of its progression.
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