阿奇霉素
药效学
药代动力学
药理学
医学
抗生素
生物
微生物学
作者
R Zań,Artur Burmańczuk,Dagmara Stępień–Pyśniak,Anna Gajda,Małgorzata Gbylik-Sikorska,Andrzej Posyniak,C. Kowalski,Tomasz Grabowski
出处
期刊:Polish Journal of Veterinary Sciences
[De Gruyter]
日期:2023-11-06
标识
DOI:10.24425/pjvs.2020.132747
摘要
To date, only a few studies on the azithromycin (AZM) pharmacokinetics in ornamental birds have been published. In the current study AZM concentrations in domestic pigeon (Columba livia domestica) plasma samples were analyzed using a validated ultra-high performance liquid chromatography tandem mass spectrometry method. The aim of the current study was to carry out an analysis of the pharmacokinetics and pharmacodynamics after administration of a single oral dose of a sustained-release AZM formulation and to conduct a simulation of treatment based on selected minimal inhibitory values. The study was performed with 12 healthy adult pigeons, both sexes. The pigeons tolerated AZM very well and no adverse effects were observed in any animal during the study. Based on the observed characteristics of the pharmacokinetics/ /pharmacodynamics profiles of AZM in pigeons, it should be noted that 35 mg/kg per os as a single starting dose and 25 mg/kg every 24 h are recommended for treatment of both suscep- tible and less susceptible pathogens.
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