A comparative study of two porous sponge scaffolds prepared by collagen derived from porcine skin and fish scales as burn wound dressings in a rabbit model

Collagen is widely used in biomedical applications due to its outstanding properties. In this study, highly porous sponge scaffolds were developed by using porcine skin-derived collagen (PSC) and fish scale-derived collagen (FSC), respectively. The morphology and composition of these PSC and FSC scaffolds were compared. The water uptake ratio of FSC scaffolds reached 47.8, which is 1.7 times of PSC scaffolds. The water vapour transmission rates (WVTR) of PSC and FSC scaffolds were 952.6 ± 55.5 and 1090.9 ± 77.1 g/m