亲脂性
化学
体内
阳离子聚合
粒度
结构-活动关系
生物物理学
体外
生物系统
纳米技术
生物化学
组合化学
有机化学
计算机科学
材料科学
生物技术
操作系统
生物
作者
Kumar Rajappan,Steven P. Tanis,Rajesh Mukthavaram,Scott J. Roberts,Michelle Nguyen,Kiyoshi Tachikawa,Amit Sagi,Marciano Sablad,Pattraranee Limphong,Angel Leu,Hailong Yu,Padmanabh Chivukula,Joseph E. Payne,Priya Karmali
标识
DOI:10.1021/acs.jmedchem.0c01407
摘要
Ionizable cationic lipids are critical components involved in nanoparticle formulations, which are utilized in delivery platforms for RNA therapeutics. While general criteria regarding lipophilicity and measured pKa in formulation are understood to have impacts on utility in vivo, greater granularity with respect to the impacts of the structure on calculated and measured physicochemical parameters and the subsequent performance of those ionizable cationic lipids in in vivo studies would be beneficial. Herein, we describe structural alterations made within a lipid class exemplified by 4, which allow us to tune calculated and measured physicochemical parameters for improved performance, resulting in substantial improvements versus the state of the art at the outset of these studies, resulting in good in vivo activity within a range of measured basicity (pKa = 6.0–6.6) and lipophilicity (cLogD = 10–14).
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