[Research progress of lung cancer with leptomeningeal metastasis].

Leptomeningeal metastases is one of the most serious complications of lung cancer, the patients with poor prognosis. Leptomeningeal metastasis in patients with lack specificity of clinical manifestations. The main clinical performance are the damage of cerebral symptoms, cranial nerve and spinal nerve. The diagnosis primarily based on the history of tumor, clinical symptoms, enhance magnetic resnance image (MRI) scan and cerebrospinal fluid cytology. In recent years, new ways of detecting clinically, significantly increase the rate of early detection of leptomeningeal metastases. The effect of comprehensive treatments are still sad. The paper make a review of research progress in pathologic physiology, clinical manifestations, diagnosis methods and treatments of lung cancer with leptomeningeal metastases. 脑膜转移是肺癌最严重的并发症之一，患者预后极差。脑膜转移患者临床表现缺乏特异性，主要表现为脑、脑神经、脊神经受累症状。目前诊断主要依据肿瘤病史、临床症状、增强核磁共振（magnetic resnance image, MRI）扫描和脑脊液细胞学检查。近年来新的检测方式在临床上不断涌现，明显提高了脑膜转移的早期发现率，但肺癌脑膜转移的综合治疗疗效仍不令人满意。本文就肺癌脑膜转移的病理生理、临床表现、诊断方法及治疗疗效的研究进展做一综述。