Relationship between eosinophils counts and muscle mass decline in older people with type 2 diabetes: A prospective study of the KAMOGAWA-DM cohort

医学 生物电阻抗分析 内科学 肌萎缩 置信区间 2型糖尿病 前瞻性队列研究 体质指数 嗜酸性粒细胞 优势比 糖尿病 队列 内分泌学 哮喘
作者
Takaaki Mastui,Yoshitaka Hashimoto,Takuro Okamura,Ayumi Kaji,Ryosuke Sakai,Yuriko Kondo,Noriyuki Kitagawa,Takufumi Senmaru,Saori Majima,Hiroshi Okada,Naoko Nakanishi,Emi Ushigome,Masahide Hamaguchi,Mai Asano,Masahiro Yamazaki,Michiaki Fukui
出处
期刊:Experimental Gerontology [Elsevier BV]
卷期号:159: 111671-111671 被引量:3
标识
DOI:10.1016/j.exger.2021.111671
摘要

Sarcopenia has become an important issue in older individuals with type 2 diabetes. However, no previous studies investigated the relationship between eosinophil count and muscle mass decline. In this prospective cohort study, we aimed to investigate this relationship in older people with type 2 diabetes. Impedance body composition was used to assess body composition and skeletal muscle mass index (SMI, kg/m2) was calculated as appendicular muscle mass (kg)/height squared (m2). The decrease in SMI (kg/m2 per year) was calculated as (baseline SMI [kg/m2] - follow-up SMI [kg/m2]) divided by the follow-up period (years). The rate of SMI decrease (%) was calculated as follows: (decrease in SMI [kg/m2 per year] ÷ baseline SMI [kg/m2]) × 100; muscle mass decline was defined as the rate of SMI decrease of ≥0.5%. Complete blood counts, including eosinophil counts, were also measured. Among 141 participants, 54.6% experienced muscle mass decline during mean (standard deviation)19.4 (7.3) months of follow-up. The eosinophil counts of participants with muscle mass decline were higher than those of participants without muscle mass decline (216.5 [147.8] vs. 158.6 [113.1] cells/mm3, p = 0.004). Eosinophil counts were negatively associated with the rate of SMI decrease according to Spearman's rank correlation coefficient (r = 0.182, p = 0.031). According to logistic regression analyses, there was the relationship between eosinophil counts and incident muscle mass decline after adjusting for covariates (odds ratio of Δ 1 incremental of logarithm (eosinophil counts) 2.04 (95% confidence interval 1.15-3.61, p = 0.011). This study showed that eosinophil counts are associated with incident muscle mass decline. If an individual with type 2 diabetes has high eosinophil counts in blood tests, then it is necessary to pay more attention to the possibility of progression of muscle atrophy.
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