肌上皮细胞
乳腺珠蛋白
乳腺癌
医学
病理
乳腺癌
CA15-3号
转移
癌症
肌上皮瘤
癌
鉴别诊断
肿瘤科
免疫组织化学
转移癌
内科学
作者
Qingqing Ding,Lei Huo,Yan Peng,Esther Yoon,Zaibo Li,Ayşegül A. Şahin
标识
DOI:10.1053/j.semdp.2022.04.002
摘要
Due to the high prevalence of breast cancer in the female, a metastasis from primary breast cancer is usually considered in the differential diagnosis of metastatic carcinoma in the female patient, even for those without a history of breast cancer, as some breast cancers are first diagnosed as metastases. Immunohistochemical analysis for breast cancer markers is the most common way to determine breast cancer origin besides clinical history and histology. In this review, we (1) summarize the commonly used and the newly identified breast cancer markers, including GCDFP-15, mammaglobin, GATA3, SOX10, and TRPS1; (2) point out the strengths and weaknesses of using these markers for breast cancers with luminal/epithelial or basal/myoepithelial differentiation; and (3) recommend diagnostic panels to differentiate breast carcinoma from carcinoma with similar morphology of other origins.
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