Protective Effects of Chrysin against Cyclophosphamide‐Induced Cardiotoxicity in Rats: A Biochemical and Histopathological Approach

心脏毒性 乳酸脱氢酶 化学 药理学 白杨素 超氧化物歧化酶 抗氧化剂 丙二醛 肌酸激酶 天冬氨酸转氨酶 谷胱甘肽过氧化物酶 谷胱甘肽 内科学 内分泌学 毒性 生物化学 医学 类黄酮 碱性磷酸酶 有机化学
作者
Bin Ye,Wenchao Ling,Yinhua Wang,Amit Jaisi,Opeyemi Joshua Olatunji
出处
期刊:Chemistry & Biodiversity [Wiley]
卷期号:19 (3) 被引量:14
标识
DOI:10.1002/cbdv.202100886
摘要

Mounting evidences have indicated that cyclophosphamide (CyC)a potent anticancer and cytotoxic agent is associated with various organ and systemic toxicities and the cytotoxic effects observed after administration of CyC still challenges its clinical use. Chrysin (Chy) is a dietary flavonoid with prevailing antioxidant and anti-inflammatory properties. This study evaluated the protective properties of Chy against CyC-induced cardiotoxicity in rats. The animals were orally treated with Chy (25 and 50 mg/kg/day) for 35 days and exposed to CyC (i. p., 100 mg/kg) once a week for four weeks. The results indicated that CyC caused significant cardiotoxicity as manifested by notable increases in heart weight, cardiac function biomarkers such as lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), troponin T and aspartate transaminase (AST). In addition, cardiac malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin 1β (IL1 β) and interleukin 6 (IL-6) levels were considerably increased. Meanwhile, cardiac antioxidant enzymes activities such as superoxide dismutase (SOD) and catalase (CAT), as well as glutathione (GSH) level were suppressed, while H&E stained histopathological assessment showed marked alterations in cardiac tissues. CyC also significantly lowered red blood cells (RBC) and white blood cells (WBC) parameters, whereas treatment with Chy significantly restored the altered biochemical and histopathological features. Conclusively, aforementioned results inferred that Chy offered cardioprotective potentials against CyC-induced cardiotoxicity which may be due to its antioxidant, and anti-inflammatory properties.
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