Dextran, as a biological macromolecule for the development of bioactive wound dressing materials: A review of recent progress and future perspectives

Skin is the largest organ in the body which plays different roles in maintaining hemostasis. Although this tissue has a high healing potential, severe skin wounds cannot heal without external interventions. Among various treatment strategies, tissue-engineered wound dressings have gained significant attention. In this regard, tremendous progress has been made in the field of tissue engineering to develop constructs with higher healing activities. Material selection and optimization are key factors in development of such dressings. Among different candidates, dextran-based wound dressings have been extensively studied. Dextran is a branched biological macromolecule which is composed of anhydroglucose monomers. Due to its excellent biocompatibility, biodegradability, non-toxicity, modifiable functional groups, and proven clinical safety, dextran has found application in wound healing research. In the current review, applications, challenges, and future perspectives of dextran-based wound dressings will be discussed.