安全药理学
临床药理学
药理学
系统药理学
医学
分子药理学
药品
内科学
受体
出处
期刊:PubMed
日期:2004-01-01
卷期号:47: 18-22
被引量:1
摘要
Safety Pharmacology is an integrated discipline that has evolved from the distinct fields of pharmacology, physiology and toxicology. Studies conducted under the guidance of 'Safety Pharmacology' are used to further the discovery, but more importantly, characterize the development of 'safe' biologically active new chemical entities (NCE). Safety Pharmacology studies identify, monitor and characterize potentially undesirable pharmacodynamic activities in non- or pre-clinical studies. This cursory review will highlight the history of Safety Pharmacology and overview the general recommendations of testing strategies used for preclinical core battery studies that are required according to the ICH regulatory S7A and S7B guidelines.
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