Congenital penile pathology is associated with abnormal development of the dartos muscle: a prospective study of primary penile surgery at a tertiary referral center.

作者
Anne-Françoise Spinoit,C. Van Praet,Luitzen Albert Groen,E. Van Laecke,Marleen Praet,Piet Hoebeke
出处
期刊:The Journal of Urology [Lippincott Williams & Wilkins]
卷期号:193 (5): 1620-1624 被引量:19
标识
DOI:10.1016/j.juro.2014.10.090
摘要

Purpose: Pathophysiological mechanisms leading to chordee in patients with hypospadias and to the hidden state of buried penis in the prepubic fat remain unclear. Resection of dartos tissue usually makes the penis straight in patients with hypospadias and corrects it in those with buried penis, suggesting a common pathophysiology related to dartos tissue.Materials and Methods: Tissue samples from 113 children undergoing primary penile surgery for hypospadias (94 patients), epispadias (1) or buried penis (18) were collected between November 2011 and September 2013. Tissue samples from 79 children undergoing circumcision for nonmedical reasons served as controls. All samples were stained with smooth muscle actin and analyzed by the same pathologist, who was blinded to indication for surgery. Chi-square and Fisher exact tests were applied.Results: Three different dartos tissue patterns were observed. Pattern I (normal) consisted of smooth muscle fibers of dartos tissue organized in a parallel configuration i...
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