奈达铂
顺铂
卡铂
奥沙利铂
抗癌药
药品
药理学
医学
临床试验
广谱
癌症
化疗
化学
内科学
组合化学
结直肠癌
作者
Jinchao Zhang,Liwei Wang,Xing Zhang,Dandan Liu,Jing Sun,Xiaoliu Li,Ying Zhang
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2010-05-01
卷期号:10 (4): 272-282
被引量:48
标识
DOI:10.2174/187152010791162270
摘要
Cisplatin has become one of the most commonly used compounds for the treatment of a wide spectrum of human malignancies. Unfortunately, cisplatin has several major drawbacks. Driven by the impressive impact of cisplatin on cancer chemotherapy, great efforts have been made to develop new derivatives with improved pharmacological properties. Among the over 30 platinum agents which have entered clinical trials after the onset of clinical studies with cisplatin in the early 1970s, only carboplatin and oxaliplatin have received worldwide approval so far, nedaplatin, lobaplatin and heptaplatin have gained regionally limited approval. It has become quite evident that mere analogues of cisplatin or carboplatin will not probably offer any substantial clinical advantages over the existing drugs. Therefore, people turned to synthesize non-classical platinum anticancer drugs which were capable of forming a different range of DNA adducts which could display a different spectrum of anticancer activity compared to cisplatin. This review will summarize the structural types and structure-activity rules of non-classical bi- and multi-nuclear platinum anticancer drugs, and discuss their future potential as anticancer agents.
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