电离辐射
真皮
医学
毛囊
细胞损伤
脱色
病理
DNA损伤
放射性皮炎
萎缩
干细胞
放射性损伤
黑素细胞
辐照
表皮(动物学)
化学
细胞
放射生物学
黑色素
辐射损伤
放射治疗
皮肤老化
辐射暴露
人体皮肤
皮下组织
急性暴露
男科
毒性
上皮
作者
Kahori Kinoshita,Hisako Ishimine,Kenshiro Shiraishi,Harunosuke Kato,Kentaro Doi,Shinichiro Kuno,Koji Kanayama,Kazuhide Mineda,Takanobu Mashiko,Jingwei Feng,Keiichi Nakagawa,Akira Kurisaki,Satoshi Itami,Kotaro Yoshimura
摘要
Ionizing radiation is often used to treat progressive neoplasms. However, the consequences of long-term radiation exposure to healthy skin tissue are poorly understood. We aimed to evaluate the short- and long-term radiation damage to healthy skin of the same irradiation given either as single or fractional doses. C57BL/J6 mice were randomly assigned to one of three groups: a control and two exposure groups (5 Gy ×2 or 10 Gy ×1). The inguinal area was irradiated (6-MeV beam) 1 week after depilation in the treatment groups. Skin samples were evaluated macroscopically and histologically for up to 6 months after the final exposure. After anagen hair follicle injury by irradiation, hair cycling resumed in both groups, but hair graying was observed in the 10 Gy ×1 group but not in the 5 Gy ×2 group, suggesting the dose of each fractional exposure is more relevant to melanocyte stem cell damage than the total dose. On the other hand, in the long term, the fractional double exposures induced more severe atrophy and capillary reduction in the dermis and subcutis, suggesting fractional exposure may cause more depletion of tissue stem cells and endothelial cells in the tissue. Thus, our results indicated that there were differences between the degrees of damage that occurred as a result of a single exposure compared with fractional exposures to ionizing radiation: the former induces more severe acute injury to the skin with irreversible depigmentation of hairs, while the latter induces long-term damage to the dermis and subcutis.
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