化学
草酸
羰基化
催化作用
钯
芳基
配体(生物化学)
一氧化碳
基质(水族馆)
组合化学
有机化学
烷基
生物化学
海洋学
地质学
受体
作者
Vandna Thakur,Ajay Kumar Sharma,Yamini Yamini,Nishtha Sharma,Pralay Das
标识
DOI:10.1002/adsc.201801127
摘要
Abstract 3‐Aryl/alkyl‐2‐quinolones were synthesized employing microwave assisted multicomponent reaction of 2‐iodoanilines, terminal alkynes and oxalic acid dihydrate ((CO 2 H) 2 ⋅ 2H 2 O) under polystyrene supported palladium (Pd@PS) nanoparticles‐catalyzed conditions. The use of a heterogeneous palladium catalyst was explored first time for 2‐quinolone synthesis involving carbonylation reaction employing (CO 2 H) 2 ⋅ 2H 2 O as a solid and bench stable carbon monoxide (CO) source. The reaction exhibited good substrate generality for 2‐iodoanilines and alkynes with wide functional group tolerance and good regio‐selectivity. The ligand free operation, recyclability of heterogeneous Pd@PS catalyst and use of bench stable C1 source are the invaluable merits of the protocol. magnified image
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