诱导多能干细胞
药物发现
疾病
药物开发
神经科学
干细胞
药品
神经干细胞
移植
生物
计算生物学
医学
胚胎干细胞
生物信息学
药理学
细胞生物学
病理
基因
外科
生物化学
作者
Juan Antonio García‐León,Javier Vitórica,Antonia Gutiérrez
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2019-06-01
卷期号:11 (11): 1305-1322
被引量:27
标识
DOI:10.4155/fmc-2018-0520
摘要
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies counteracting the disease progression. The advent of human pluripotent stem cells has revolutionized the field allowing the generation of disease-relevant neural cell types that can be used for disease modeling, drug screening and, possibly, cell transplantation purposes. In this Review, we discuss the applications of human pluripotent stem cells, the development of efficient protocols for the derivation of the different neural cells and their applicability for robust in vitro disease modeling and drug screening platforms for most common neurodegenerative conditions.
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