Blood glucose mediated the effects of cognitive function impairment related to aluminum exposure in Chinese aluminum smelting workers

认知 蒙特利尔认知评估 医学 认知评估系统 调解 内科学 心理学 认知障碍 精神科 政治学 法学
作者
Shimeng Xu,Baolong Pan,Dan Gao,Yunwei Zhang,Jiaping Huan,Xiao Han,Jianliang Song,Linping Wang,Huifang Zhang,Na Qiao,Xiaoting Lu
出处
期刊:Neurotoxicology [Elsevier]
卷期号:91: 282-289 被引量:4
标识
DOI:10.1016/j.neuro.2022.06.001
摘要

To explore the effects of occupational aluminum exposure on workers' cognitive function and blood glucose concentration, and to analyze whether blood glucose concentration can mediate the cognitive changes caused by aluminum.Our study recruited 375 workers from an aluminum factory in northern China. We collected the fasting elbow venous blood of the workers, measured their fasting blood glucose concentration (FBG), and used ICP-MS to determine plasma aluminum concentration (P-Al) as an indicator of internal exposure. The Montreal Cognitive Assessment (MoCA), was used to assess the cognitive function of workers. Generalized linear model was used to analyze the association of P-Al with cognitive function and blood glucose concentration, and the restricted cubic spline model was used to fit the dose-response relationship. We also conducted a mediation effect analysis.We observed the dose-response relationship, that is, as the P-Al increased, sum of MoCA, visuospatial/executive, naming, language, and abstraction scores decreased, and the blood glucose concentration increased. For every e-fold increase in P-Al, sum of MoCA, visuospatial/executive, naming, language, and abstraction scores decreased by 0.328 points, 0.120 points, 0.059 points, 0.060 points, and 0.083 points, respectively, and FBG rose by 0.109 mmol/L. FBG has a significant mediating effect between P-Al and sum of MoCA (P for mediator=0.042), and it could explain 10.7% of the effect of cognitive level related to P-Al.Occupational aluminum exposure negatively affected the cognitive function of workers and positively affected FBG. FBG may partially explain the impact of occupational aluminum exposure on workers' cognitive function.
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