Cucurbituril-Based Supramolecular Assemblies: Prospective on Drug Delivery, Sensing, Separation, and Catalytic Applications

Precise control over the stimuli-responsive noncovalent interactions operative in a complex molecular system has emerged as a convenient way to realize applications in the detection and sensing of trace analytes, metal ion separation, uptake-release, in situ nanoparticle synthesis, and catalytic activity. This feature article focuses on the attributes and advantages of noncovalent host-guest interactions involving cucurbituril homologues (CBs) with a wide range of organic and inorganic guests, starting from organic dyes to drugs, proteins, surfactants, metal ions, and polyoxometalates. The unique structural features of CBs provide interaction sites for cations at the portals, polyanions at the periphery, and hydrophobic groups in its cavity. The facile complexation and consequent compositional and geometrical arrangements of guests such as naphthalenediimides, coumarins, porphyrins, and triphenylpyrylium ions with the host CBs led to remarkable changes in many molecular properties, especially aggregation, the proton binding and release affinity, and novel emissive dimers, and each of such spectroscopic signatures have been appropriately channeled to drug delivery and activation to improve the antibacterial efficacy and shelf life of drugs by increasing their photostability. Several technological advantages have also been extracted from the interaction of CBs with inorganic guests as well. The interaction of CB7 with the heptamolybdate anion resulted in the precipitation of a hybrid complex material which enabled a convenient separation methodology for the use of clinically pure radioactive ^99mTc in diagnostic applications. Certain cucurbituril-based hybrid materials have been developed for enhanced SO₂ adsorption at low pressures, high-efficiency hydrogen production, and reversible catalytic systems. Thus, this feature article provides a glimpse of the vast potential of cucurbituril homologues with organic and inorganic guests and calls for a dedicated effort to explore supramolecular strategies for better sensors, therapeutics, smart drug delivery modules, and facile devices.