结直肠癌
化学
细胞凋亡
立体化学
碳-13核磁共振
细胞培养
IC50型
癌细胞系
质子核磁共振
体外
细胞生长
芳基
癌症
癌细胞
生物化学
生物
有机化学
医学
内科学
烷基
遗传学
作者
Bin-Lu Nong,Xiangwei Meng,Yingying Wei,Huajun Zhao,Xingxian Zhang
标识
DOI:10.1080/10286020.2022.2067533
摘要
A series of structurally modified curcumol derivatives at C-8 position were designed and synthesized, whose structures were confirmed by 1H NMR,13C NMR, and HRMS analysis. The tested compounds were evaluated for in vitro antitumor activity against colorectal cancer cell lines SW620, HCT116, and CaCo2. Many of the tested candidates exhibited higher inhibition efficiency than curcumol. Among them, compound 3 l shows the best inhibitory effect on the viability of SW620 with IC50 value of 19.90 ± 0.64 µM. The structure-activity relationships of these derivatives were discussed, which showed that the introduction of amino or aryl groups tended to increase the anti-cancer activity. In addition, compound 3 l may inhibit cancer cell proliferation through triggering cell apoptosis.
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