化学
烯烃
溴
邻接
催化作用
基质(水族馆)
卤化
有机化学
组合化学
海洋学
地质学
作者
Lei Wang,Lele Zhai,Jinyan Chen,Yulin Gong,Peng Wang,Huilin Li,Xuegong She
标识
DOI:10.1021/acs.joc.1c02906
摘要
A direct 1,2-dibromination method of alkenes is realized using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as a bromine source. This reaction proceeds under mild reaction conditions without the use of a catalyst and an external oxidant. Various sorts of alkene substrates are transformed into the corresponding 1,2-dibrominated products in good to excellent yields with broad substrate scope and exclusive diastereoselectivity. This method offers a green and practical approach to synthesize vicinal dibromide compounds.
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