去甲肾上腺素
慢性疲劳综合征
肾上腺素
儿茶酚胺能
内科学
医学
内分泌学
儿茶酚胺
交感神经系统
刺激
自主神经系统
唤醒
心理学
心率
血压
多巴胺
神经科学
作者
Jana Strahler,Susanne Fischer,Urs M. Nater,Ulrike Ehlert,Jens Gaab
标识
DOI:10.1016/j.biopsycho.2013.06.002
摘要
Chronic fatigue syndrome (CFS) is characterized by fatigue lasting 6 months or longer. CFS has been associated with a disturbed (re-)activity of the autonomic nervous system. However, the sympathetic adrenomedulla (SAM) remains under-examined in CFS. To investigate SAM reactivity, we implemented a submaximal cycle ergometry (ERGO) and a pharmacological test (Insulin Tolerance Test, ITT) in 21 CFS patients and 20 age-, sex-, and BMI-matched controls. Plasma norepinephrine and epinephrine were collected once before and twice after the tests (+10/+20, and +30 min). Lower baseline levels and attenuated responses of epinephrine to the ERGO were found in CFS patients compared to controls, while the groups did not differ in their responses to the ITT. To conclude, we found evidence of altered sympathetic-neural and SAM reactivity in CFS. Exercise stress revealed a subtle catecholaminergic hyporeactivity in CFS patients. It is conceivable that inadequate catecholaminergic responses to physical exertion might contribute to CFS symptoms.
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