生物
基因组
系统发育学
微生物群
肠道菌群
计算生物学
人体微生物群
人类健康
进化生物学
生物信息学
遗传学
基因
免疫学
医学
环境卫生
作者
Alan W. Walker,Sylvia H. Duncan,Petra Louis,Harry J. Flint
标识
DOI:10.1016/j.tim.2014.03.001
摘要
The human intestinal tract is colonised by a complex community of microbes, which can have major impacts on host health. Recent research on the gut microbiota has largely been driven by the advent of modern sequence-based techniques, such as metagenomics. Although these are powerful and valuable tools, they have limitations. Traditional culturing and phylogeny can mitigate some of these limitations, either by expanding reference databases or by assigning functionality to specific microbial lineages. As such, culture and phylogeny will continue to have crucially important roles in human microbiota research, and will be required for the development of novel therapeutics.
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