Norepinephrine Inhibits the Pelvic Pressure Increase in Response to Flow Perfusion

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Jul 2003Norepinephrine Inhibits the Pelvic Pressure Increase in Response to Flow Perfusion U. HOLST, T. DISSING, Y.F. RAWASHDEH, J. FROKIAER, J.C. DJURHUUS, and J. MORTENSEN U. HOLSTU. HOLST More articles by this author , T. DISSINGT. DISSING More articles by this author , Y.F. RAWASHDEHY.F. RAWASHDEH More articles by this author , J. FROKIAERJ. FROKIAER More articles by this author , J.C. DJURHUUSJ.C. DJURHUUS More articles by this author , and J. MORTENSENJ. MORTENSEN More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000069824.13258.14AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the effects of norepinephrine on transport pressures in the normal upper urinary tract of the pig during increasing perfusion rates. Materials and Methods: Anesthetized Danish landrace Yorkshire pigs weighing 38 to 40 kg were studied. Transparenchymally 2, 6Fr catheters were introduced into the left renal pelvis for pressure measurements and perfusion, respectively. An ultrasonic flow probe was inserted around the left renal artery to record blood flow. A 10Fr catheter was placed transurethrally for bladder drainage and the bladder was maintained empty during the entire study. In the 5 group 1 pigs the pelvic pressure increase was examined at increasing perfusion rates of the renal pelvis (2, 4, 6, 8, 10 and 15 ml per minute) in response to endoluminal administration of increasing concentrations of norepinephrine (0, 5, 50 and 100 μg/ml) in saline. In the 5 group 2 pigs the pressure flow study was also done 4 times per animal using isotonic saline. Results: Endoluminal norepinephrine had a dose dependent effect on the pressure flow relationship. Perfusion with 5 and 50 μg/ml norepinephrine caused a delayed increase and a decrease in pelvic pressure in response to increasing flow rates, whereas perfusion with 100 μg/ml norepinephrine significantly inhibited and almost eliminated the pressure increase at all perfusion rates compared with saline perfusion. Importantly there were no changes in blood pressure, the heart rate or renal arterial blood flow. In group 2 perfusion with isotonic saline resulted in the same pressure response to increasing flow rates each time. Conclusions: Endoluminal administration of norepinephrine caused a dose dependent inhibition on the pressure phases of the pressure flow relationship of the upper urinary tract in pigs. No systemic changes were observed. These observations may provide a useful adjuvant treatment strategy for upper urinary tract stone treatment and endoscopy. References 1 : Renal pelvic pacemaker control of ureteral peristaltic rate. Am J Physiol1974; 226: 1413. 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Volume 170Issue 1July 2003Page: 268-271 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsurodynamicsnorepinephrineurinary tractswineMetricsAuthor Information U. HOLST More articles by this author T. DISSING More articles by this author Y.F. RAWASHDEH More articles by this author J. FROKIAER More articles by this author J.C. DJURHUUS More articles by this author J. MORTENSEN More articles by this author Expand All Advertisement PDF downloadLoading ...