适体
介孔二氧化硅
纳米颗粒
细胞毒性
纳米技术
介孔材料
癌症
癌细胞
材料科学
化学
组合化学
体外
生物化学
分子生物学
医学
生物
内科学
催化作用
作者
Lucas Torres Miranda Sá,Suzanne Simmons,Sotiris Missailidis,Maria Isabel Pais da Silva,Ralph Santos‐Oliveira
标识
DOI:10.3109/1061186x.2012.761222
摘要
The use of mesoporous silica for cancer targeting is increasing rapidly. The association between rigid model of nanoparticles such as mesoporous silica and biological compounds with affinity for oncological diseases is a very promising drug targeting system nowadays.In this study, we used the mesoporous silica (SBA-15) associated with aptamer (functionalized for the tumor marker MUC-1).The results obtained in the characterization were quite interesting and demonstrated that the silica produced were very uniform and with a size range of 50-100 nm. Thus, the results of cytotoxicity demonstrated that there is no cytotoxicity related to the nanoparticle.We conclude that although further studies are required, the nanoparticle mesoporous silica model loaded with aptamer is very functional and its use can be widespread for other application especially in nuclear medicine.
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