Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men

生物 全基因组关联研究 遗传学 钴胺素 单核苷酸多态性 遗传关联 疾病 维生素B12 基因 基因型 病理 医学 内分泌学
作者
Xiaoling Lin,Daru Lu,Yong Gao,Shasha Tao,Xiaobo Yang,Junjie Feng,Aihua Tan,Haiying Zhang,Yanling Hu,Xuejun Qin,Seong‐Tae Kim,Tao Peng,Li Li,Linjian Mo,Shijun Zhang,Jeffrey M. Trent,Zengnan Mo,S. Lilly Zheng,Jianfeng Xu,Jielin Sun
出处
期刊:Human Molecular Genetics [Oxford University Press]
卷期号:21 (11): 2610-2617 被引量:62
标识
DOI:10.1093/hmg/dds062
摘要

Vitamin B12 (VitB12 or cobalamin) is an essential cofactor in several metabolic pathways. Clinically, VitB12 deficiency is associated with pernicious anemia, neurodegenerative disorder, cardiovascular disease and gastrointestinal disease. Although previous genome-wide association studies (GWAS) identified several genes, including FUT2, CUBN, TCN1 and MUT, that may influence VitB12 levels in European populations, common genetic determinants of VitB12 remain largely unknown, especially in Asian populations. Here we performed a GWAS in 1999 healthy Chinese men and replicated the top findings in an independent Chinese sample with 1496 subjects. We identified four novel genomic loci that were significantly associated with serum level of VitB12 at a genome-wide significance level of 5.00 × 10−8. These four loci were MS4A3 (11q12.1; rs2298585; P= 2.64 × 10−15), CLYBL (13q32; rs41281112; P= 9.23 × 10−10), FUT6 (19p13.3; rs3760776; P= 3.68 × 10−13) and 5q32 region (rs10515552; P= 3.94 × 10−8). In addition, we also confirmed the association with the serum level of VitB12 for the previously reported FUT2 gene and identified one novel non-synonymous single-nucleotide polymorphism in FUT2 gene in this Chinese population (19q13.33; rs1047781; P= 3.62 × 10−36). The new loci identified offer new insights into the biochemical pathways involved in determining the serum level of VitB12 and provide opportunities to better delineate the role of VitB12 in health and disease.
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