硫醇
半胱氨酸
谷胱甘肽
化学
胶体金
氨基酸
同型半胱氨酸
纳米颗粒
反应性(心理学)
组合化学
有机化学
生物化学
纳米技术
酶
材料科学
病理
替代医学
医学
作者
Felicia X. Zhang,Li Han,Lisa B. Israel,Jason G. Daras,Mathew M. Maye,Nam K. Ly,Chuan Jian Zhong
出处
期刊:Analyst
[The Royal Society of Chemistry]
日期:2002-03-11
卷期号:127 (4): 462-465
被引量:180
摘要
This paper reports findings of an investigation of the unusual colorimetric change of gold nanoparticles in the presence of thiol-containing amino acids such as homocysteine, cysteine and glutathione. The colorimetric change for homocysteine exhibits a rate that is about two orders of magnitude higher than that for cysteine, and at least five orders of magnitude higher than that for glutathione. The reactivity is effectively reduced or suppressed by the coexistence of either cysteine or glutathione. It is believed that the reactivity involves encapsulation of the particles by the thiol-containing amino acids which is followed by crosslinking at the encapsulating shells. In comparison with cysteine and glutathione, homocysteine has a slower encapsulating rate but a faster crosslinking rate. Implications of the findings of the interfacial encapsulation and crosslinking reactivities of gold nanoparticles to potential nanoparticle-enhanced analytical detection of thiol-containing amino acids are also briefly discussed.
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