神经退行性变
热休克蛋白
神经保护
肌萎缩侧索硬化
蛋白质折叠
蛋白质聚集
伴侣(临床)
药物发现
药品
神经科学
未折叠蛋白反应
疾病
热休克蛋白70
医学
生物
化学
细胞生物学
生物信息学
药理学
生物化学
内质网
病理
基因
作者
Muhammad Sajjad,Ben Samson,Andreas Wyttenbach
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2010-02-01
卷期号:11 (2): 198-215
被引量:27
标识
DOI:10.2174/138920110790909641
摘要
Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases ("proteinopathies"). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimers- and Parkinsons disease, the polyglutamine- and prion disorders and Amyotrophic Lateral Sclerosis.
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