化学
环加成
区域选择性
戒指(化学)
组合化学
催化作用
有机化学
作者
Sara Aly,Mikhail Romashko,Bruce A. Arndtsen
摘要
A new, one-pot synthesis of imidazoles from imines, acid chlorides, and N-nosyl imines or tethered nitriles is reported. The reaction is mediated by the phosphonite PPh(catechyl) and proceeds via regioselective cycloaddition with an in situ-generated phospha-münchnone 1,3-dipole. This provides an efficient route to construct both highly substituted and polycyclic imidazoles directly from available substrates, without metal catalysts, and with access to product diversity.
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