霍乱弧菌
群体感应
铜绿假单胞菌
自诱导物
微生物学
细菌
病菌
生物
弧菌
人类病原体
化学
生物膜
遗传学
作者
Hadas Ganin,Yael Danin‐Poleg,Yechezkel Kashi,Michaël M. Meijler
摘要
The human pathogen Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main autoinducer is CAI-1. We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were unaffected, and we suggest a possible mechanism for these effects, based on membrane perturbation studies.
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