In the relentless pursuit of quantum computational advantage, we present a significant advancement with the development of Zuchongzhi 3.0. This superconducting quantum computer prototype, comprising 105 qubits, achieves high operational fidelities, with single-qubit gates, two-qubit gates, and readout fidelity at 99.90%, 99.62% and 99.18%, respectively. Our experiments with an 83-qubit, 32-cycle random circuit sampling on Zuchongzhi 3.0 highlight its superior performance, achieving one million samples in just a few hundred seconds. This task is estimated to be infeasible on the most powerful classical supercomputers, Frontier, which would require approximately $6.4\times 10^9$ years to replicate the task. This leap in processing power places the classical simulation cost six orders of magnitude beyond Google's SYC-67 and SYC-70 experiments [Nature 634, 328(2024)], firmly establishing a new benchmark in quantum computational advantage. Our work not only advances the frontiers of quantum computing but also lays the groundwork for a new era where quantum processors play an essential role in tackling sophisticated real-world challenges.