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Association of Infant Breastfeeding and Juvenile Spondyloarthritis: A Case-Control Study

医学 母乳喂养 联想(心理学) 少年 儿科 母乳喂养 哲学 认识论 生物 遗传学
作者
Katelyn H. Baggett,Timothy G. Brandon,Rui Xiao,Pamela F. Weiss
出处
期刊:The Journal of Rheumatology [The Journal of Rheumatology]
卷期号:51 (7): 708-714
标识
DOI:10.3899/jrheum.2023-1203
摘要

Objective Given the multifactorial pathogenesis of juvenile spondyloarthritis (JSpA) and evidence of a protective effect in phenotypically similar diseases, we aimed to test whether breastfeeding is associated with the development and disease activity of JSpA. Methods This single-center retrospective case-control study included children with JSpA and age- and sex-matched controls with a 1:1 ratio. Univariable and multivariable conditional logistic regression modeling for matched pairs was used to test the association of infant factors with the development of JSpA, including infant nutrition and form of delivery. Linear regression was used to assess the association of JSpA disease activity (JSpA Disease Activity Index with 6 elements [JSpADA6]) at presentation with breastfeeding exposure, form of delivery, and antibiotic exposure. Results For the 195 case-control matched pairs, the mean age was 13.0 years and 47.7% were female. For breastfeeding, 88.7% of controls and 69.2% of JSpA cases were exposed to breastfeeding of any duration, respectively ( P < 0.001). In the multivariable model, exclusive breastfeeding > 6 months was independently and significantly associated with a lower chance of JSpA development (odds ratio 0.47, 95% CI 0.30-0.72; P < 0.001). The median JSpADA6 was not significantly associated with breastfeeding for > 6 months. However, vaginal delivery was significantly associated with a lower JSpADA6 (B = −0.65, 95% CI −1.13 to −0.17; P = 0.008). Conclusion This study suggests that infant factors that affect the microbiome may be associated with the occurrence and disease activity of JSpA at presentation.

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