生命历程法
流行病学
公共卫生
观察研究
人口
老年学
医学
社会流行病学
心理学
健康的社会决定因素
环境卫生
发展心理学
病理
作者
Cornelia Wagner,Cristian Carmeli,Josephine Jackisch,Mika Kivimäki,B. Lindén,Stéphane Cullati,Arnaud Chioléro
标识
DOI:10.1016/s2468-2667(24)00018-5
摘要
Life course epidemiology aims to study the effect of exposures on health outcomes across the life course from a social, behavioural, and biological perspective. In this Review, we describe how life course epidemiology changes the way the causes of chronic diseases are understood, with the example of hypertension, breast cancer, and dementia, and how it guides prevention strategies. Life course epidemiology uses complex methods for the analysis of longitudinal, ideally population-based, observational data and takes advantage of new approaches for causal inference. It informs primordial prevention, the prevention of exposure to risk factors, from an eco-social and life course perspective in which health and disease are conceived as the results of complex interactions between biological endowment, health behaviours, social networks, family influences, and socioeconomic conditions across the life course. More broadly, life course epidemiology guides population-based and high-risk prevention strategies for chronic diseases from the prenatal period to old age, contributing to evidence-based and data-informed public health actions. In this Review, we assess the contribution of life course epidemiology to public health and reflect on current and future challenges for this field and its integration into policy making.
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