Microwave-assisted palladium-catalyzed conjugate addition of arylsilanes to alkynes

Organosilanes, extensively employed as nucleophiles in coupling reactions, have seen limited application in the catalytic regioselective addition to unsaturated hydrocarbons. In this study, we present a microwave-assisted, palladium-catalyzed conjugate addition reaction involving arylsilanes and activated alkynes. This methodology for the catalytic functionalization of alkynes with organosilicon reagents offers a straightforward route to creating multisubstituted alkenes, boasting high regioselectivity. This efficient and versatile reaction tolerates a broad range of functional groups and substrates, heralding a potent new avenue in synthetic strategy.