急性呼吸窘迫综合征
转录组
无症状的
基因
弥漫性肺泡损伤
免疫学
基因表达
医学
表观遗传学
基因表达谱
生物
内科学
肺
急性呼吸窘迫
遗传学
作者
Alexander Rombauts,Marta Bódalo‐Torruella,Gabriela Abelenda-Alonso,Júlia Perera-Bel,Anna Ferrer-Salvador,Ariadna Acedo-Terrades,Maria Gabarrós-Subirà,Isabel Oriol,Carlota Gudiol,Lara Nonell,Jordi Carratalà
出处
期刊:Biomedicines
[MDPI AG]
日期:2023-05-03
卷期号:11 (5): 1348-1348
被引量:4
标识
DOI:10.3390/biomedicines11051348
摘要
The clinical manifestations of SARS-CoV-2 infection vary widely, from asymptomatic infection to the development of acute respiratory distress syndrome (ARDS) and death. The host response elicited by SARS-CoV-2 plays a key role in determining the clinical outcome. We hypothesized that determining the dynamic whole blood transcriptomic profile of hospitalized adult COVID-19 patients and characterizing the subgroup that develops severe disease and ARDS would broaden our understanding of the heterogeneity in clinical outcomes. We recruited 60 hospitalized patients with RT-PCR-confirmed SARS-CoV-2 infection, among whom 19 developed ARDS. Peripheral blood was collected using PAXGene RNA tubes within 24 h of admission and on day 7. There were 2572 differently expressed genes in patients with ARDS at baseline and 1149 at day 7. We found a dysregulated inflammatory response in COVID-19 ARDS patients, with an increased expression of genes related to pro-inflammatory molecules and neutrophil and macrophage activation at admission, in addition to an immune regulation loss. This led, in turn, to a higher expression of genes related to reactive oxygen species, protein polyubiquitination, and metalloproteinases in the latter stages. Some of the most significant differences in gene expression found between patients with and without ARDS corresponded to long non-coding RNA involved in epigenetic control.
科研通智能强力驱动
Strongly Powered by AbleSci AI