Health effects of exposure to sulfur dioxide, nitrogen dioxide, ozone, and carbon monoxide between 1980 and 2019: A systematic review and meta‐analysis

Indoor AirVolume 32, Issue 11 e13170 REVIEW Health effects of exposure to sulfur dioxide, nitrogen dioxide, ozone, and carbon monoxide between 1980 and 2019: A systematic review and meta-analysis Zhuoru Chen, Zhuoru Chen School of Public Health, Fudan University, Shanghai, China Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, ChinaSearch for more papers by this authorNingrui Liu, Ningrui Liu Department of Building Science, Tsinghua University, Beijing, ChinaSearch for more papers by this authorHao Tang, Hao Tang School of Public Health, Fudan University, Shanghai, China Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, ChinaSearch for more papers by this authorXuehuan Gao, Xuehuan Gao Anhui Provincial Center for Disease Control and Prevention, Hefei, ChinaSearch for more papers by this authorYinping Zhang, Yinping Zhang Department of Building Science, Tsinghua University, Beijing, ChinaSearch for more papers by this authorHaidong Kan, Haidong Kan School of Public Health, Fudan University, Shanghai, China Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, ChinaSearch for more papers by this authorFurong Deng, Furong Deng orcid.org/0000-0002-2801-4389 School of Public Health, Peking University, Beijing, ChinaSearch for more papers by this authorBin Zhao, Bin Zhao orcid.org/0000-0003-1325-6091 Department of Building Science, Tsinghua University, Beijing, ChinaSearch for more papers by this authorXiangang Zeng, Xiangang Zeng School of Environment and Natural Resources, Renmin University of China, Beijing, ChinaSearch for more papers by this authorYuexia Sun, Yuexia Sun School of Environmental Science and Engineering, Tianjin University, Tianjin, ChinaSearch for more papers by this authorHua Qian, Hua Qian orcid.org/0000-0002-7237-7806 School of Energy and Environment, Southeast University, Nanjing, ChinaSearch for more papers by this authorWei Liu, Wei Liu Institute for Health and Environment, Chongqing University of Science and Technology, Chongqing, ChinaSearch for more papers by this authorJinhan Mo, Jinhan Mo orcid.org/0000-0002-3178-6507 Department of Building Science, Tsinghua University, Beijing, ChinaSearch for more papers by this authorXiaohong Zheng, Xiaohong Zheng School of Energy and Environment, Southeast University, Nanjing, ChinaSearch for more papers by this authorChen Huang, Chen Huang School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, ChinaSearch for more papers by this authorChanjuan Sun, Chanjuan Sun orcid.org/0000-0001-7728-9461 School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, ChinaSearch for more papers by this authorZhuohui Zhao, Corresponding Author Zhuohui Zhao [email protected] orcid.org/0000-0001-8596-0278 School of Public Health, Fudan University, Shanghai, China Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China Shanghai Typhoon Institute/CMA, Shanghai Key Laboratory of Meteorology and Health, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, WMO/IGAC MAP-AQ Asian Office Shanghai, Fudan University, Shanghai, China Correspondence Zhuohui Zhao, School of Public Health, Fudan University, Building 8, Dong'an Road 130, Shanghai 200032, China. Email: [email protected]Search for more papers by this author Zhuoru Chen, Zhuoru Chen School of Public Health, Fudan University, Shanghai, China Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, ChinaSearch for more papers by this authorNingrui Liu, Ningrui Liu Department of Building Science, Tsinghua University, Beijing, ChinaSearch for more papers by this authorHao Tang, Hao Tang School of Public Health, Fudan University, Shanghai, China Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, ChinaSearch for more papers by this authorXuehuan Gao, Xuehuan Gao Anhui Provincial Center for Disease Control and Prevention, Hefei, ChinaSearch for more papers by this authorYinping Zhang, Yinping Zhang Department of Building Science, Tsinghua University, Beijing, ChinaSearch for more papers by this authorHaidong Kan, Haidong Kan School of Public Health, Fudan University, Shanghai, China Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, ChinaSearch for more papers by this authorFurong Deng, Furong Deng orcid.org/0000-0002-2801-4389 School of Public Health, Peking University, Beijing, ChinaSearch for more papers by this authorBin Zhao, Bin Zhao orcid.org/0000-0003-1325-6091 Department of Building Science, Tsinghua University, Beijing, ChinaSearch for more papers by this authorXiangang Zeng, Xiangang Zeng School of Environment and Natural Resources, Renmin University of China, Beijing, ChinaSearch for more papers by this authorYuexia Sun, Yuexia Sun School of Environmental Science and Engineering, Tianjin University, Tianjin, ChinaSearch for more papers by this authorHua Qian, Hua Qian orcid.org/0000-0002-7237-7806 School of Energy and Environment, Southeast University, Nanjing, ChinaSearch for more papers by this authorWei Liu, Wei Liu Institute for Health and Environment, Chongqing University of Science and Technology, Chongqing, ChinaSearch for more papers by this authorJinhan Mo, Jinhan Mo orcid.org/0000-0002-3178-6507 Department of Building Science, Tsinghua University, Beijing, ChinaSearch for more papers by this authorXiaohong Zheng, Xiaohong Zheng School of Energy and Environment, Southeast University, Nanjing, ChinaSearch for more papers by this authorChen Huang, Chen Huang School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, ChinaSearch for more papers by this authorChanjuan Sun, Chanjuan Sun orcid.org/0000-0001-7728-9461 School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, ChinaSearch for more papers by this authorZhuohui Zhao, Corresponding Author Zhuohui Zhao [email protected] orcid.org/0000-0001-8596-0278 School of Public Health, Fudan University, Shanghai, China Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China Shanghai Typhoon Institute/CMA, Shanghai Key Laboratory of Meteorology and Health, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, WMO/IGAC MAP-AQ Asian Office Shanghai, Fudan University, Shanghai, China Correspondence Zhuohui Zhao, School of Public Health, Fudan University, Building 8, Dong'an Road 130, Shanghai 200032, China. Email: [email protected]Search for more papers by this author First published: 18 November 2022 https://doi.org/10.1111/ina.13170Citations: 1 Zhuoru Chen and Ningrui Liu Co-first authors Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The burden of disease attributed to the indoor exposure to sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), and carbon monoxide (CO) is not clear, and the quantitative concentration–response relationship is a prerequisite. This is a systematic review to summarize the quantitative concentration–response relationships by screening and analyzing the polled effects of population-based epidemiological studies. After collecting literature published between 1980 and 2019, a total of 19 health outcomes in 101 studies with 182 health risk estimates were recruited. By meta-analysis, the leave-one-out sensitivity analysis and Egger's test for publication bias, the robust and reliable effects were found for SO2 (per 10 μg/m3) with chronic obstructive pulmonary diseases (COPD) (pooled relative risks [RRs] 1.016, 95% CI: 1.012–1.021) and cardiovascular diseases (CVD) (RR 1.012, 95%CI: 007–1.018), respectively. NO2 (per 10 μg/m3) had the pooled RRs for childhood asthma, preterm birth, lung cancer, diabetes, and COPD by 1.134 (1.084–1.186), 1.079 (1.007–1.157), 1.055 (1.010–1.101), 1.019 (1.009–1.029), and 1.016 (1.012–1.120), respectively. CO (per 1 mg/m3) was significantly associated with Parkinson's disease (RR 1.574, 95% CI: 1.069–2.317) and CVD (RR 1.024, 95% CI: 1.011–1.038). No robust effects were observed for O3. This study provided evidence and basis for further estimation of the health burden attributable to the four gaseous pollutants. CONFLICT OF INTEREST The authors declared that they have no competing interests. Open Research DATA AVAILABILITY STATEMENT The data that support the findings of this study are available in the supplementary material of this article. Supporting Information Filename Description ina13170-sup-0001-AppendixS1.docxWord 2007 document , 3.2 MB Appendix S1 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1Collaborators GRF. 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